Correlation between umuC induction and Salmonella mutagenicity assay for quinolone antimicrobial agents
نویسندگان
چکیده
منابع مشابه
Pharmacodynamics of Quinolone Antimicrobial Agents
Pharmacodynamics describes the relationship between measures of drug levels in serum and tissue fluids and the antimicrobial and toxicologic effects of drugs (5, 10, 17, 49). While there have been numerous studies describing the pharmacokinetics of fluoroquinolones in serum and tissues, there has been much less emphasis on describing the time course of antimicrobial activity with these drugs. T...
متن کاملQuinolone Antimicrobial Agents, 3rd Edition
The quinolone class is one of the more important classes of antimicrobial agents discovered in recent years and one of the most widely used classes of antimicrobial drugs in clinical medicine. Their broad spectrum of activity and pharmacokinetic properties make the quinolone agents ideal for treating a variety of infections. Their clinical importance is further demonstrated by their activity ag...
متن کاملThe Ames Salmonella/microsome mutagenicity assay.
The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads to gene mutations. The test employs several histidine dependent Salmonella strains each carrying different mutations in various genes in the histidine operon. ...
متن کاملPrediction of Salmonella mutagenicity.
The ability of a number of prediction systems was examined to determine how well they could predict Salmonella mutagenicity. The prediction systems included two computer-based systems (CASE and TOPKAT), the measurement of a physiochemical parameter (ke) and the use of structural alerts by an expert chemist. The computer-based systems operators and the chemist were supplied with the structures o...
متن کاملThe Salmonella Mutagenicity Assay: The Stethoscope of Genetic Toxicology for the 21st Century
OBJECTIVES According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has been central to the field of genetic toxicology since the 1970s. Here we doc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1993
ISSN: 0378-1097
DOI: 10.1016/0378-1097(93)90608-5